This bill modifies U.S. policy and establishes requirements with respect to knowledge diplomacy (i.e., the role of international science and technology agreements in foreign relations). Specifically, the bill declares it to be U.S. policy that federally supported international science and technology agreements should serve U.S. national security and economic interests. Further, it requires the Department of State to (1) identify vulnerabilities in international cooperation that may place federally funded research at risk, (2) strengthen the security and integrity of U.S. scientific and research collaborations with foreign partners, and (3) encourage the international scientific community to adopt and adhere to U.S. scientific values. The bill also requires the White House Office of Science and Technology Policy to submit a biennial report on compliance with U.S. policy across such science and technology agreements.