Cleaner, Quieter Airplanes Act This bill directs the National Aeronautics and Space Administration (NASA) to establish an initiative to build upon and accelerate previous or ongoing work to develop and demonstrate new technologies in aircraft concepts that are capable of reducing both greenhouse gas emissions and noise emissions from aircraft by at least 50%. The goal of the initiative shall be to deploy new technologies developed pursuant to the initiative on (1) regional transport aircraft intended to enter into service by 2030, and (2) single-aisle aircraft designed to accommodate more than 125 passengers intended to enter into service by 2040.