John S. McCain Opioid Addiction Prevention Act This bill establishes a new registration requirement for practitioners who are licensed to prescribe controlled substances in schedule II, III, or IV. Specifically, a practitioner must agree to limit the supply of opioids prescribed for the initial treatment of acute pain, as a condition of obtaining or renewing a registration through the Drug Enforcement Administration. An opioid that is approved and prescribed for the treatment of addiction is not subject to the limit.