Appalachia Opportunity Grants Act of 2018 This bill amends the Consolidated Farm and Rural Development Act to authorize the Department of Agriculture to award grants for units of local government in the Appalachian region of the eastern United States to convene groups of public and private entities to collaborate in carrying out regional projects to accomplish positive economic and community impacts in the region. A regional project carried out by a collaborative group must: (1) involve at least two municipalities that share a border; and (2) complete a specific activity that has a goal of job creation, expansion of the capacity of post-secondary education, growth of tourism, improving public health, or upgrading regional infrastructure.