To improve the ability of the Federal Government to address synthetic opioids, and for other purposes.

Comprehensive Fentanyl Control Act This bill amends the Controlled Substances Act to modify the drug quantity thresholds that trigger a mandatory minimum prison term for a defendant who manufactures, distributes, or possesses with intent to distribute fentanyl. It also establishes a consecutive mandatory prison term for a defendant who commits a drug offense involving a detectable amount of heroin or fentanyl. The bill establishes a rebuttable presumption that the illegal manufacture of a controlled substance that contains a detectable amount of heroin or fentanyl creates a substantial risk of harm to human life. The Drug Enforcement Administration may temporarily place a drug or substance into schedule I based on a finding: (1) that the drug or substance satisfies the criteria for being a synthetic opioid, and (2) that adding it will prevent abuse or misuse. The bill makes it a crime to knowingly mail to an unauthorized person equipment that may be used to manufacture counterfeit controlled substances. A violator is subject to criminal penalties. Finally, it makes it a crime to import, export, manufacture, distribute, dispense, or possess with intent to manufacture, distribute, or dispense, a synthetic opioid that is not clearly labeled. A violator is subject to criminal and civil penalties.