Protect and Grow American Jobs Act This bill amends the Immigration and Nationality Act to revise the definition of "exempt H-1B nonimmigrant" to eliminate the masters or higher degree requirement and raise the annual salary threshold requirement from $60,000 to $100,000. (An exempt H-1B nonimmigrant is a nonimmigrant H-1B [specialty occupation] worker meeting certain criteria whom an H-1B dependent employer may hire without having to satisfy certain otherwise applicable H-1B hiring criteria. An H-1B dependent employer is generally one whose H-1B workers comprise 15% or more of the employer's total workforce, with different thresholds applying to smaller employers.) The bill requires an inflation adjustment to the salary threshold every third fiscal year.